How to create auto responder for Plesk Anbalagi Krishnan Modified on: Mon, 15 May, 2023 at 11:14 AM To set a auto responder on Plesk services, please follow the simple steps below:Login to your Plesk control panel. Once logged in, please click on Mail. Please click on the email address (not the checkbox) that you wish to have the auto responder, and click on the auto-reply tab. Click on checkbox for Switch on auto-reply and fill the necessary field. Once you are done, click on OK.